Auxin-induced SCF–Aux IAA interaction involves stable modification of the SCF complex
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منابع مشابه
Auxin signaling and regulated protein degradation.
Auxin regulates many aspects of plant growth and development. Auxin is known to regulate gene expression through degradation of the AUX/IAA proteins, short-lived nuclear proteins that regulate gene transcription. The AUX/IAA proteins are degraded through the action of a ubiquitin protein ligase called SCF. Auxin promotes the interaction between AUX/IAA proteins and SCF in a soluble extract, sug...
متن کاملAuxin receptors and plant development: a new signaling paradigm.
The plant hormone auxin, in particular indole-3-acetic acid (IAA), is a key regulator of virtually every aspect of plant growth and development. Auxin regulates transcription by rapidly modulating levels of Aux/IAA proteins throughout development. Recent studies demonstrate that auxin perception occurs through a novel mechanism. Auxin binds to TIR1, the F-box subunit of the ubiquitin ligase com...
متن کاملAuxin
Most commonly found as… … Indole-3-acetic acid or IAA. What is it? IAA is a weak acid similar to tryptophan. Its existence was first suggested by the Darwin brothers as a compound responsible for 'the power of movement in plants', but it was not named and chemically defined until much later. What does it do? Everything! What, everything? Yes, auxin apparently regulates almost everything in plan...
متن کاملArabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase.
Auxin response in Arabidopsis thaliana requires the SCF(TIR1) ubiquitin ligase. In response to the hormone, SCF(TIR1) targets members of the auxin/indoleacetic acid (Aux/IAA) family of transcriptional regulators for ubiquitin-mediated proteolysis. To identify additional regulators of SCF(TIR1) activity, we conducted a genetic screen to isolate enhancers of the tir1-1 auxin response defect. Here...
متن کاملArabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis.
The AXR6 gene is required for auxin signaling in the Arabidopsis embryo and during postembryonic development. One of the effects of auxin is to stimulate degradation of the Aux/IAA auxin response proteins through the action of the ubiquitin protein ligase SCF(TIR1). Here we show that AXR6 encodes the SCF subunit CUL1. The axr6 mutations affect the ability of mutant CUL1 to assemble into stable ...
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تاریخ انتشار 2017